Project Summary
FOXG1 is a key transcription factor essential for brain development, with mutations leading to FOXG1 syndrome, a severe neurodevelopmental disorder. Beyond its nuclear role, FOXG1 interacts with diverse protein machineries across cellular compartments, influencing critical processes such as mitochondrial function and RNA regulation. Using human brain organoids as a model system, we aim to investigate the dynamic FOXG1 interactome during neurodevelopment, with a focus on its localisation within protein machinery and interaction networks in a cell-type-specific manner. Furthermore, we will characterise the functional consequences of patient-specific FOXG1 mutations that disrupt these interactions, shedding light on the mechanisms underlying FOXG1 syndrome.
