The SFB 1381 investigates how different proteins are dynamically assembled into complex multimers, the so-called protein machineries, which play a central role e.g. in the energy metabolism of the cell, the replication, repair, and transcription of DNA, the folding and degradation of proteins, as well as the intra- and intercellular communication and transport processes. The focus of the SFB 1381 lies on the organization of these protein machineries in modular units, the regulation of their assembly and disassembly, and the impact of these processes on cellular functions.
The aim of the SFB 1381 is to define and understand the dynamic processes of the assembly and organization of cellular protein machineries, and to gain insight into the fundamental processes in a living cell.
Imagefilm of SFB 1381. Video Jürgen Gocke. Also available on Youtube
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Marada, A., Walter, C., Suhm, T., Shankar, S., Nandy, A., Brummer, T., Dhaouadi, I., Vogtle, F. N. and Meisinger, C. (2024) DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring. Nat Commun 15(1), 5265
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Vollmar, L., Schimpf, J., Hermann, B. and Hugel, T. (2024) Cochaperones convey the energy of ATP hydrolysis for directional action of Hsp90. Nat. Commun. 15, 569
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Xu, F., Li, R., von Gromoff, E. D., Drepper, F., Knapp, B., Warscheid, B., Baumeister, R. and Qi, W. (2023) Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans. Nat Commun 14(1), 4176
Becker, F., Fuchs, S., Refisch, L., Drepper, F., Bildl, W., Schulte, U., Liang, S., Heinicke, J. I., Hansen, S. C., Kreutz, C., Warscheid, B., Fakler, B., Mymrikov, E. V. and Hunte, C. (2023) Conformational regulation and target-myristoyl switch of calcineurin B homologous protein 3. Elife 12
Sarmah, P., Shang, W., Origi, A., Licheva, M., Kraft, C., Ulbrich, M., Lichtenberg, E., Wilde, A. and Koch, H.G. (2023) mRNA targeting eliminates the need for the signal recognition particle during membrane protein insertion in bacteria. Cell Reports 42(3), 112140
Schulte, U., den Brave, F., Haupt, A., Gupta, A., Song, J., Müller, C. S., Engelke, J., Mishra, S., Mårtensson, C., Ellenrieder, L., Priesnitz, C., Straub, S. P., Doan, K. N., Kulawiak, B., Bildl, W., Rampelt, H., Wiedemann, N., Pfanner, N., Fakler, B., and Becker, T. (2023) Mitochondrial complexome reveals quality-control pathways of protein import. Nature 614, 153–159
Gaines, M. C., Isupov, M. N., Sivabalasarma, S., Haque, R. U., McLaren, M., Mollat, C. L., Tripp, P., Neuhaus, A., Gold, V. A. M., Albers, S. V., and Daum, B. (2022) Electron cryo-microscopy reveals the structure of the archaeal thread filament. Nat Commun. 13(1), 7411
van Wolferen, M., Pulschen, A. A., Baum, B., Gribaldo, S., and Albers, S. V. (2022) The cell biology of archaea. Nat Microbiol. 7(11), 1744-1755
Diessl, J., Berndtsson, J., Broeskamp, F., Habernig, L., Kohler, V., Vazquez-Calvo, C., Nandy, A., Peselj, C., Drobysheva, S., Pelosi, L., Vögtle, F. N., Pierrel, F., Ott, M., and Büttner, S. (2022) Manganese-driven CoQ deficiency. Nat Commun. 13(1), 6061
Götz, M., Barth, A., Bohr, S., Börner, R., Chen. J., Cordes, T., Erie, D., Gebhardt, C., Hadzic, M., Hamilton, G., Hatzakis, N., Hugel, T., Kisley, L., Lamb, D., de Lannoy, C., Mahn, C., Dunukara., D., de Ridder, D., Sanabria, H., Schimpf, J., Seidel, C., Sigel, R., Sletfjerding, M., Thomsen, J., Vollmar, L., Wanninger, S., Weninger, K., Xu, P., and Schmid, S. (2022) A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories. Nat. Commun. 13, 5402
Müller, C., Zhang, L., Zipfel, S., Topitsch, A., Lutz, M., Eckert, J., Prasser, B., Chami, M., Lü, W., Du, J., and Einsle, O. (2022) Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature 608, 626-631
Vögtle, F.N., Koch, H.G., and Meisinger, C. (2022) A common evolutionary origin reveals fundamental principles of protein insertases. PLoS Biol 20(3), e3001558
Morgenstern, M., Peikert, C.D., Lübbert, P., Suppanz, I., Klemm, C., Alka, O., Steiert, C., Naumenko, N., Schendzielorz, A., Melchionda, L., Mühlhäuser, W.W.D., Knapp, B., Busch, J.D., Stiller, S.B., Dannenmaier, S., Lindau, C., Licheva, M., Eickhorst, C., Galbusera, R., Zerbes, R.M., Ryan, M.T., Kraft, C., Kozjak-Pavlovic, V., Drepper, F., Dennerlein, S., Oeljeklaus, S., Pfanner, N., Wiedemann, N., and Warscheid, B. (2021) Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell. Metab. 33(12), 2464-2483, e18
Yousefi, O.S., Ruggieri, M., Idstein, V., von Prillwitz, K.U., Herr, L.A., Chalupsky, J., Köhn, M., Weber, W., Timmer, J., and Schamel, W.W.A. (2021) Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding. Int. J. Mol. Sci. 22, 4920
Agne, M., Estelmann, S., Seelmann, C. S., Kung, J., Wilkens, D., Koch, H.G., van der Does, C., Albers, S. V., von Ballmoos, C., Simon, J., and Boll, M. (2021) The missing enzymatic link in syntrophic methane formation from fatty acid. Proc. Natl. Acad. Sci. U S A 118(40), e2111682118