The Goal of the SFB 1381
The SFB 1381 investigates how different proteins are dynamically assembled into complex multimers, the so-called protein machineries, which play a central role e.g. in the energy metabolism of the cell, the replication, repair, and transcription of DNA, the folding and degradation of proteins, as well as the intra- and intercellular communication and transport processes. The focus of the SFB 1381 lies on the organization of these protein machineries in modular units, the regulation of their assembly and disassembly, and the impact of these processes on cellular functions.
The aim of the SFB 1381 is to define and understand the dynamic processes of the assembly and organization of cellular protein machineries, and to gain insight into the fundamental processes in a living cell.
Imagefilm of SFB 1381. Video Jürgen Gocke. Also available on Youtube
Seminars
News
Selected Publications
Grzejda, D., Hess, A., Rezansoff, A., Gorey, S., Carrasco, J., Alfonso-Gonzalez, C., Tsagkris, S., Neuhaus, L., Shi, M., Ozbulut, H. C., Vögtle, F.-N., Vlachos, A. and Hilgers, V. (2025) Pumilio differentially binds to mRNA 3′ UTR isoforms to regulate localization of synaptic proteins. EMBO reports 1-24-24
Licheva, M., Pflaum, J., Babic, R., Mancilla, H., Elsässer, J., Boyle, E., Hollenstein, D. M., Jimenez-Niebla, J., Pleyer, J., Heinrich, M., Wieland, F.-G., Brenneisen, J., Eickhorst, C., Brenner, J., Jiang, S., Hartl, M., Welsch, S., Hunte, C., Timmer, J., Wilfling, F. and Kraft, C. (2025) Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy. Nature Cell Biology
Njenga, R. K., Boele, J., Drepper, F., Sinha, K., Marouda, E., Huesgen, P. F., Blaby-Haas, C. and Koch, H. G. (2024) Ribosome-inactivation by a class of widely distributed C-tail anchored membrane proteins. Structure 32(12), 2259-2275 e2256
Marada, A., Walter, C., Suhm, T., Shankar, S., Nandy, A., Brummer, T., Dhaouadi, I., Vogtle, F. N. and Meisinger, C. (2024) DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring. Nat Commun 15(1), 5265
Eickhorst, C., Babic, R., Rush-Kittle, J., Lucya, L., Lami Imam, F., Sanchez-Martin, P., Hollenstein, D. M., Michaelis, J., Munch, C., Meisinger, C., Slade, D., Gamez-Diaz, L. and Kraft, C. (2024) FIP200 phosphorylation regulates late steps in mitophagy. J Mol Biol 168631
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Administration
Gabriele Reindl
Institute of Biochemistry and Molecular Biology
University of Freiburg
